Boosting hair follicle regeneration
نویسندگان
چکیده
منابع مشابه
Modulating hair follicle size with Wnt10b/DKK1 during hair regeneration.
Hair follicles have characteristic sizes corresponding to their cycle-specific stage. However, how the anagen hair follicle specifies its size remains elusive. Here, we showed that in response to prolonged ectopic Wnt10b-mediated β-catenin activation, regenerating anagen hair follicles grew larger in size. In particular, the hair bulb, dermal papilla and hair shaft became enlarged, while the fo...
متن کاملWnt5a Suppresses β-catenin Signaling during Hair Follicle Regeneration
Hair follicles display periodic growth. Wnt signaling is a critical regulator for hair follicle regeneration. Previously, we reported that Wnt5a inhibits the telogen-to-anagen transition of hair follicles, but the mechanism by which this process occurs has not yet been reported. Here, we determined the expression patterns of Wnt signaling pathway molecules by quantitative reverse transcription ...
متن کاملThe role of Lhx2 in hair follicle morphogenesis and regeneration
5 Paper in this licentiate thesis 7 Abbreviations 8 Introduction 9 The hair follicle 9 Hair follicle morphogenesis 10 Molecular regulation of the HF morphogenesis 12 The hair cycle 13 Catagen 14 Telogen 15 Anagen 15 LIM-homeodomain transcription factors 18 Lhx2 19 Aim 21 Results and discussion 22 Expression of Lhx2 during HF morphogenesis and postnatal cycling 22 Transgenic over-expression of L...
متن کاملAugmenting Peripheral Nerve Regeneration Using Rat Hair Follicle Stem Cells (rHFSCs) in Rats
Introduction: Nowadays, cell therapy is the most advanced treatment of peripheral nerve injury. The aim of this study was to determine the effects of transplantation of hair follicle stem cells on the regeneration of the sciatic nerve injury in rats. Methods: The bulge region of the rat whisker was isolated and cultured. Morphological and biological features of the cultured bulge cells were ob...
متن کاملHair follicle nevus.
We present a case of hair follicle nevus, a rare hamartoma composed of vellus hair follicles. Hair follicle nevus should be differentiated from accessory auricle, trichofolliculoma and hair nevus.
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2013
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd4095